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Potential Herbal Solution Reversing Progression of Alzheimer's Disease

Lifestyle influences can lower the likelihood of Alzheimer's onset. However, once contracted, treatment options have been limited. Nevertheless, new research spotlights a herb believed to slow Alzheimer's progression and even restore normal brain function.

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Lifestyle choices can lower the likelihood of Alzheimer's onset, but once diagnosed, treatment...
Lifestyle choices can lower the likelihood of Alzheimer's onset, but once diagnosed, treatment options have been limited. However, recent studies introduce an herb that reportedly slows down the progression and even reverses the impact on the brain...

Potential Herbal Solution Reversing Progression of Alzheimer's Disease

New Research Offers Potential Breakthrough in Alzheimer's Treatment

A California-based research team has discovered a synthetic compound called diAcCA, which shows promising results in combating Alzheimer's disease (AD) pathology. The compound is an altered version of carnosic acid, a naturally occurring anti-inflammatory and neuroprotective agent found in common herbs like rosemary and sage.[1][2]

DiAcCA was engineered to improve carnosic acid's stability and effectiveness, making it a viable option for potential AD treatments. In preclinical studies using AD mouse models, diAcCA:

  1. Crossed the Blood-Brain Barrier: DiAcCA successfully entered the brain, where it converted into bioactive carnosic acid before reaching the bloodstream.[1]
  2. Improved Memory and Synaptic Density: Treated mice showed improved performance in cognitive tests such as water mazes, alongside increased synaptic density as revealed by immunohistochemical analysis.[1][3]
  3. Reduced Brain Inflammation: DiAcCA specifically targeted and reduced inflammation in affected brain regions, potentially minimizing broader side effects.[1]
  4. Dismantled Toxic Proteins: Early data indicate that diAcCA may help break down harmful proteins such as phosphorylated tau and amyloid-β, key players in Alzheimer's disease progression.[1]
  5. Had a Good Safety Profile: The compound was well-tolerated, and interestingly, also appeared to reduce baseline inflammation in the esophagus and stomach as it converted to carnosic acid.[1]

Since carnosic acid is already recognized by the FDA as "generally regarded as safe," researchers believe clinical trials for diAcCA in humans may be imminent.[1] Study author Stuart Lipton suggests that diAcCA could be used alone or in combination with existing Alzheimer's therapies, potentially reducing side effects such as amyloid-related imaging abnormalities.[1]

These findings highlight diAcCA as a novel prodrug with potential to regenerate brain connections and tackle multiple aspects of Alzheimer's disease, pending further clinical validation. The mice in the study absorbed 20 percent more carnosic acid through diAcCA than they would have from ingesting pure carnosic acid, allowing more of the compound to pass through the blood-brain barrier. [1]

If you are looking to potentially reduce your Alzheimer's risk, adding more rosemary and sage to your cooking or consuming them in tea could be beneficial. However, caution is advised for those sensitive to aspirin, bleeding disorders, or seizure disorders.[4]

[1] Compound found in common herbs inspires potential anti-inflammatory drug for Alzheimer’s disease - Scripps Research[2] Ingredient hidden in your spice rack could reverse Alzheimer's disease - Daily Mail[3] diAcCA, a Pro-Drug for Carnosic Acid That Activates the Nrf2 Transcriptional Pathway, Shows Efficacy in the 5xFAD Transgenic Mouse Model of Alzheimer's Disease - Antioxidants[4] Preventing or Slowing Down Alzheimer's Disease and Dementia - HelpGuide.org[5] What are the Causes and Risk Factors of Alzheimer's and Other Dementias? - Alzheimer's Association

  1. The synthetic compound diAcCA, derived from carnosic acid found in common herbs like rosemary and sage, has potential as a medical-condition treatment, particularly in neurological disorders such as Alzheimer's disease.
  2. In a recent study, the compound diAcCA was found to reduce brain inflammation, a key factor in Alzheimer's disease progression, making it a potential candidate for health-and-wellness purposes.
  3. Fitness-and-exercise aside, the consumption of rosemary and sage, which contain the anti-inflammatory agent carnosic acid, may potentially lower one's Alzheimer's risk.
  4. As diAcCA is a synthetic version of a naturally occurring anti-inflammatory and neuroprotective agent, its safety profile could be advantageous when compared to other medical-condition treatments, particularly in the field of science and Alzheimer's disease research.

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