Dosage Information for Oxbryta: Forms, Potency Levels, Administration Guidelines, and Related Details
Oxbryta, a brand-name drug, is used to treat sickle cell disease (SCD) in adults and children aged 4 years and older. This medication is a long-term treatment option, and it comes in two forms: oral tablets and oral suspension (liquid mixture).
For children with SCD, the dosage depends on their body weight. Children aged 12 years and older receive the same dosage as adults, which is 1500 mg once daily. For children between 4 and younger than 12 years, the dosage varies based on weight:
- Children weighing 40 kg or more are prescribed 1500 mg once daily.
- Children weighing between 20 and less than 40 kg are given 900 mg once daily.
- Children weighing between 10 and less than 20 kg are prescribed 600 mg once daily.
Use in children younger than 4 years is not established and should be determined by a doctor.
Adults (and children 12 years and older) receive a fixed dosage of 1500 mg once daily, regardless of weight.
It's important to note that Oxbryta was voluntarily recalled in September 2024 due to emerging safety concerns, including risks that outweighed benefits in some patients.
If you're having trouble opening medication bottles, ask your pharmacist about easy-open containers. For those who find it difficult to swallow tablets, there are tips and tools available to help.
Remember, the dosage of Oxbryta can be affected by other medications, medical conditions, and liver disease. If you believe you've taken too much Oxbryta, call your doctor right away or use the America's Poison Centers hotline.
Oxbryta tablets for oral suspension come in one strength of 300 mg and two strengths: 300 milligrams (mg) and 500 mg. To use the oral suspension, dissolve the tablets in a clear liquid at room temperature and then swallow the mixture. The tablets should not be divided, crushed, chewed, or placed in water.
If you miss a dose of Oxbryta, skip the missed dose and take your next scheduled dose at your regular time on the following day. Do not take more than the recommended amount of Oxbryta.
Pharmacies may offer labels with large print, braille, or a code to convert text to speech to aid those with visual impairments.
In summary, the key difference in dosing between children and adults is that children under 12 receive weight-based dosing, while adults and older children receive a standard 1500 mg daily dose. Always consult with your healthcare provider for personalised advice on dosage and treatment.
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