CRTD Unveils 'First Responder' Pancreatic Cells in Blood Sugar Regulation
An international team, led by Prof. Nikolay Ninov at the Center for Regenerative Therapies Dresden (CRTD), is delving into the intricacies of blood sugar regulation. Their focus? The role of vitamin B6 in metabolic diseases and type 2 diabetes. The team is exploring whether all beta cells in the pancreas react equally to blood sugar levels, with a particular interest in a subset of beta cells they've dubbed 'First Responder' cells.
These First Responder cells are more sensitive and respond faster to blood sugar fluctuations than their counterparts. They produce a key enzyme that activates vitamin B6, which the team suspects may regulate the activity of other beta cells. The team is investigating if low vitamin B6 levels could be linked to the onset of metabolic diseases and type 2 diabetes.
To study this, the researchers are observing young zebrafish. Their transparent skin provides a unique window into the pancreas, allowing direct observation of the beta cells in action. The team's work could pave the way for new insights into diabetes development and potentially, new treatment methods.
The CRTD team, led by Prof. Ninov, is unraveling the mysteries of blood sugar regulation, with a keen eye on the role of vitamin B6 and the unique function of First Responder cells. Their research, using young zebrafish as a model, could lead to significant advancements in our understanding of diabetes and other metabolic diseases, and potentially, new avenues for treatment.
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