Austrian Breakthrough: New System for Evaluating Cancer Diagnostic Radiopharmaceuticals
Austrian researchers have developed a groundbreaking system for evaluating radioactive substances used in cancer diagnostics. The innovative method, presented in the Journal of Nuclear Medicine, aligns with the 3R principle and the FDA's Critical Path Initiative.
The Spheriograph project, funded by the Austrian Research Promotion Agency (FFG), has created a system that combines chromatographic principles with a dynamic 3D cell culture on a silk matrix. This matrix, made from silk fibroin, offers radiation stability and proven cell culture advantages.
The system enables real-time observation of radiopharmaceutical drugs using μPET/CT imaging techniques. It also allows accurate evaluation of binding properties, target accuracy, and potential side effects of test radioactive marker substances. Notably, it eliminates the need for animal testing, providing automated, fast, and highly precise analyses.
The research team, led by Innocent Meat in collaboration with the University of Rostock's Chair of Microfluidics, has developed an innovative 3D cell culture facility. Human cells are immobilized in a three-dimensional structure using biocompatible silk fibroin sponges. This method was developed by an Austrian consortium of research groups and DOC Medikus GmbH.
The new system offers a significant advancement in cancer diagnostics, providing accurate, fast, and humane evaluations of radioactive substances. It aligns with international ethical and regulatory standards, marking a step forward in the field. For further information, contact Innocent Meat or the University of Rostock's relevant department.
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